The aim of present work was to develop a robust formulation of Bi-layer tablets of diclofenac sodium tablet. The basic aim of Bi-layer tablet formulation is to produce immediate action or prolonged action tablet. Wet granulation process was used for the formulation of matrix tablet layers and direct compression method process was used for the formulation of fast disintegrating layer of tablet. Tablets were evaluated for the thickness, weight variation, hardness, friability, disintegration time, dissolution study and compiled all the parameters with the official specifications. Based on the release kinetic parameters calculated, the drug contained in the fast disintegrating layer dissolved within the first 6 min & drug contained in the matrix layer dissolved upto 6 hr, so it can be concluded that tablets were particularly suitable for fast & long lasting action.
Loading....